KMID : 1199120090330010031
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Korean Diabetes Journal 2009 Volume.33 No. 1 p.31 ~ p.39
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Average Daily Risk Range-Index of Glycemic Variability-Related Factor in Type 2 Diabetic Inpatients
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Park Shin-Ae
Ko Seung-Hyun Lee Seung-Hwan Cho Jae-Hyoung Moon Sung-Dae Jang Sang-A Song Ki-Ho Son Hyun-Shik Yoon Kun-Ho Cha Bong-Yun Son Ho-Young Ahn Yu-Bae
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Abstract
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Background: It is known that chronic sustained hyperglycemia and its consequent oxidative stress causes diabetic complication in type 2 diabetes. It has been further proven that glycemic variability causes oxidative stress. The aim of this study is to measure the average daily risk range (ADDR)-index of glycemic variability, and to evaluate relevant variables.
Methods: We measured the blood glucose level of type 2 diabetic patients who were treated with multiple daily injections from January to July, 2008. The blood glucose levels were checked four times a day for 14 days and were conversed according to the ADRR formula. The degree of glycemic variability was categorized into non-fluctuation and fluctuation groups. We collected patient data on age, sex, duration of diabetes, body mass index, HOMAIR, HOMA¥âcell and HbA1c.
Results: A total of 97 patients were enrolled in this study. The mean age, duration of diabetes, HbA1c and mean ADRR were 57.6 ¡¾ 13.4, 11.5 ¡¾ 8.5 years, 10.7 ¡¾ 2.5%, and 26.6 ¡¾ 9.8, respectively. We classified 18.5% of the patients to the non-fluctuation group, and 81.5% to the fluctuation group. ADRR was significantly correlated with duration of diabetes, fasting and postprandial glucose, fructosamine, HbA1c and BMI and HOMA¥âcell. In addition, this study confirmed that BMI, HOMA¥âcell and HbA1c were ADRR-related independent variables.
Conclusion: ADRR can be used as an index for blood glucose fluctuation in type 2 diabetic patients. Measuring ADRR in patients with low BMI and a long duration of diabetes is helpful to improve the effectiveness of their care.
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KEYWORD
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Blood glucose, Variability, Type 2 diabetes mellitus
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